Polymersome-based drug-delivery strategies for cancer therapeutics

Ther Deliv. 2015;6(4):521-34. doi: 10.4155/tde.14.125.


Polymersomes are stable vesicles prepared from amphiphilic polymers and are more stable compared with liposomes. Although these nanovesicles have many attractive properties for in vitro/in vivo applications, liposome-based drug delivery systems are still prevalent in the market. In order to expedite the translational potential and to provide medically valuable formulations, the polymersomes need to be biocompatible and biodegradable. In this review, recent developments for biocompatible and biodegradable polymersomes, including the design of intelligent, targeted, and stimuli-responsive vesicles are summarized.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Drug Delivery Systems / methods*
  • Humans
  • Models, Biological
  • Molecular Targeted Therapy / methods
  • Nanospheres / administration & dosage*
  • Nanospheres / chemistry*
  • Neoplasms / drug therapy*
  • Pharmaceutical Preparations / administration & dosage*
  • Polymers / administration & dosage*
  • Polymers / chemical synthesis
  • Polymers / chemistry*


  • Pharmaceutical Preparations
  • Polymers