Osmostress-induced gene expression--a model to understand how stress-activated protein kinases (SAPKs) regulate transcription

FEBS J. 2015 Sep;282(17):3275-85. doi: 10.1111/febs.13323. Epub 2015 Jun 10.


Adaptation is essential for maximizing cell survival and for cell fitness in response to sudden changes in the environment. Several aspects of cell physiology change during adaptation. Major changes in gene expression are associated with cell exposure to environmental changes, and several aspects of mRNA biogenesis appear to be targeted by signaling pathways upon stress. Exhaustive reviews have been written regarding adaptation to stress and regulation of gene expression. In this review, using osmostress in yeast as a prototypical case study, we highlight those aspects of regulation of gene induction that are general to various environmental stresses as well as mechanistic aspects that are potentially conserved from yeast to mammals.

Keywords: Hog1; SAPK; gene expression; mammals; osmostress; p38; stress responses; yeast.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptation, Physiological / genetics
  • Animals
  • Cell Cycle / genetics
  • Chromatin Assembly and Disassembly
  • Gene Expression Regulation, Fungal*
  • Mitogen-Activated Protein Kinases / genetics*
  • Mitogen-Activated Protein Kinases / metabolism
  • Osmotic Pressure*
  • RNA, Long Noncoding / genetics
  • RNA, Long Noncoding / metabolism
  • RNA, Messenger / biosynthesis
  • RNA, Messenger / genetics*
  • Saccharomyces cerevisiae / enzymology
  • Saccharomyces cerevisiae / genetics*
  • Saccharomyces cerevisiae Proteins / genetics*
  • Saccharomyces cerevisiae Proteins / metabolism
  • Signal Transduction
  • Stress, Physiological / genetics
  • Transcription, Genetic*


  • RNA, Long Noncoding
  • RNA, Messenger
  • Saccharomyces cerevisiae Proteins
  • HOG1 protein, S cerevisiae
  • Mitogen-Activated Protein Kinases