Using opioid receptors to expand the chemogenetic and optogenetic toolbox

Neuron. 2015 May 20;86(4):853-855. doi: 10.1016/j.neuron.2015.05.014.


In this issue of Neuron, innovative new modifications to opioid receptors are used to expand the tools available to modulate neuronal activity. Vardy et al. (2015) describe a new "DREADD" chemogenetic tool based on the inhibitory κ opioid receptor (KORD) that can be used in conjunction with already-available DREADDs. Siuda et al. (2015) report the development of "opto-MOR," a light-activatable μ opioid receptor (MOR) chimera that can be used to better understand the complexities of MOR signaling.

Publication types

  • Comment

MeSH terms

  • Analgesics, Opioid / pharmacology*
  • Animals
  • Behavior, Animal / drug effects*
  • Diterpenes / pharmacology*
  • GABAergic Neurons / drug effects*
  • Neurons / drug effects*
  • Optogenetics*
  • Receptors, Opioid, kappa / metabolism*
  • Receptors, Opioid, mu / metabolism*
  • Signal Transduction / drug effects*


  • Analgesics, Opioid
  • Diterpenes
  • Receptors, Opioid, kappa
  • Receptors, Opioid, mu