Ruthenium-catalyzed oxidative coupling of 2-aryl-4-quinazolinones with olefins: synthesis of pyrrolo[2,1-b]quinazolin-9(1H)-one motifs

Org Biomol Chem. 2015 Jun 21;13(23):6474-8. doi: 10.1039/c5ob00601e. Epub 2015 May 21.

Abstract

A ruthenium-catalyzed oxidative coupling of 2-aryl-quinazolinones with olefins via C-H bond activation followed by an intramolecular aza-Michael reaction is described. This strategy allows the direct and efficient construction of pyrrolo[2,1-b]quinazolin-9(1H)-one scaffolds.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemistry*
  • Catalysis
  • Chemistry Techniques, Synthetic
  • Oxidative Coupling*
  • Quinazolinones / chemical synthesis*
  • Quinazolinones / chemistry
  • Ruthenium / chemistry*

Substances

  • Alkenes
  • Quinazolinones
  • Ruthenium