Severe gastrointestinal toxicity with administration of trametinib in combination with dabrafenib and ipilimumab

Pigment Cell Melanoma Res. 2015 Sep;28(5):611-2. doi: 10.1111/pcmr.12383. Epub 2015 Jun 23.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Aged
  • Antibodies, Monoclonal / administration & dosage*
  • Antibodies, Monoclonal / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Clinical Trials as Topic
  • Colitis / chemically induced*
  • Colon / drug effects
  • Female
  • Humans
  • Imidazoles / administration & dosage*
  • Imidazoles / adverse effects
  • Immunotherapy / methods
  • Ipilimumab
  • Melanoma / complications
  • Melanoma / drug therapy*
  • Middle Aged
  • Oximes / administration & dosage*
  • Oximes / adverse effects
  • Pyridones / administration & dosage*
  • Pyridones / adverse effects
  • Pyrimidinones / administration & dosage*
  • Pyrimidinones / adverse effects
  • Skin Neoplasms / complications
  • Skin Neoplasms / drug therapy*

Substances

  • Antibodies, Monoclonal
  • Imidazoles
  • Ipilimumab
  • Oximes
  • Pyridones
  • Pyrimidinones
  • trametinib
  • dabrafenib