Objective: To evaluate the relationship between maternal formaldehyde exposure during pregnancy and spontaneous abortion.
Methods: A computerized literature search was carried out to collect articles published before 2014. The study types included case-control and cohort studies. And then the statistical analysis was conducted by using RevMan 5. 1 software.
Results: A total of 6 studies were included in Meta-analysis (totally 666 subjects and 3087 controls) according to the selection criteria. Because all the studies selected were homogeneous (I2 = 37% , P = 0. 16) , the fixed effect model was used for calculation of the combined OR values. Compared with the control, maternal formaldehyde exposure during pregnancy was significantly associated with spontaneous abortion (OR = 1. 64, 95% CI 1. 20 - 2. 24, P = 0. 002).
Conclusion: Maternal formaldehyde exposure during pregnancy may increase the risk of spontaneous abortion.