1 ICSN-CNRS, Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles du CNRS, CNRS UPR 2301, 1 Avenue de la Terrasse, F-91198 Gif-sur-Yvette, France. stephanie.norsikian@cnrs.fr jean-marie.beau@u-psud.fr.
The three-component Petasis borono-Mannich reaction starting with easily accessible N-protected α-amino aldehydes produces efficiently and diastereoselectively 1,2-trans-diamines with an enantiomeric excess of up to 98%.