Reversible pH-controlled switching of an artificial antioxidant selenoenzyme based on pseudorotaxane formation and dissociation

Jiaxi Li; Chengye Si; Hongcheng Sun; Junyan Zhu; Tiezheng Pan; Shengda Liu; Zeyuan Dong; Jiayun Xu; Quan Luo; Junqiu Liu

doi:10.1039/c5cc02038g

Reversible pH-controlled switching of an artificial antioxidant selenoenzyme based on pseudorotaxane formation and dissociation

Chem Commun (Camb). 2015 Jun 21;51(49):9987-90. doi: 10.1039/c5cc02038g.

Authors

Jiaxi Li¹, Chengye Si, Hongcheng Sun, Junyan Zhu, Tiezheng Pan, Shengda Liu, Zeyuan Dong, Jiayun Xu, Quan Luo, Junqiu Liu

Affiliation

¹ Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Road, Changchun 130012, People's Republic of China. junqiuliu@jlu.edu.cn.

PMID: 25998200
DOI: 10.1039/c5cc02038g

Abstract

A pH-responsive artificial selenoenzyme was constructed by reversible binding between organoselenium compound a1 nd CB[6] to form a pseudorotaxane-based molecular switch in response to pH stimuli. The glutathione peroxidase (GPx) activity of the artificial selenoenzyme can be switched on/off in a mild and body suitable environment between pH = 7 and pH = 6.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biomimetic Materials / chemistry*
Bridged-Ring Compounds / chemistry
Glutathione Peroxidase / chemistry
Glutathione Peroxidase / metabolism*
Hydrogen-Ion Concentration
Imidazoles / chemistry
Models, Molecular
Molecular Conformation
Organoselenium Compounds / chemistry*
Rotaxanes / chemistry*

Substances

Bridged-Ring Compounds
Imidazoles
Organoselenium Compounds
Rotaxanes
cucurbit(6)uril
Glutathione Peroxidase