MicroRNA biogenesis pathways in cancer

Nat Rev Cancer. 2015 Jun;15(6):321-33. doi: 10.1038/nrc3932.


MicroRNAs (miRNAs) are critical regulators of gene expression. Amplification and overexpression of individual 'oncomiRs' or genetic loss of tumour suppressor miRNAs are associated with human cancer and are sufficient to drive tumorigenesis in mouse models. Furthermore, global miRNA depletion caused by genetic and epigenetic alterations in components of the miRNA biogenesis machinery is oncogenic. This, together with the recent identification of novel miRNA regulatory factors and pathways, highlights the importance of miRNA dysregulation in cancer.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biological Transport
  • Clustered Regularly Interspaced Short Palindromic Repeats
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Mice
  • MicroRNAs / physiology*
  • Neoplasms / genetics*
  • Neoplasms / metabolism
  • RNA Processing, Post-Transcriptional


  • MicroRNAs