Ca(2+) homeostasis and endoplasmic reticulum (ER) stress: An integrated view of calcium signaling

Biochem Biophys Res Commun. 2015 Apr 24;460(1):114-21. doi: 10.1016/j.bbrc.2015.02.004.


Cellular Ca(2+) homeostasis is maintained through the integrated and coordinated function of Ca(2+) transport molecules, Ca(2+) buffers and sensors. These molecules are associated with the plasma membrane and different cellular compartments, such as the cytoplasm, nucleus, mitochondria, and cellular reticular network, including the endoplasmic reticulum (ER) to control free and bound Ca(2+) levels in all parts of the cell. Loss of nutrients/energy leads to the loss of cellular homeostasis and disruption of Ca(2+) signaling in both the reticular network and cytoplasmic compartments. As an integral part of cellular physiology and pathology, this leads to activation of ER stress coping responses, such as the unfolded protein response (UPR), and mobilization of pathways to regain ER homeostasis.

Keywords: Ca(2+) homeostasis; Ca(2+)-binding proteins; Calcium transport; ER stress; Membrane contact sites; MicroRNAs; Unfolded protein response (UPR).

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Calcium Channels / physiology*
  • Calcium Signaling / physiology*
  • Endoplasmic Reticulum / metabolism*
  • Homeostasis / physiology*
  • Humans
  • Ion Channel Gating / physiology*
  • Models, Biological
  • Stress, Physiological / physiology*


  • Calcium Channels
  • Calcium