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. 2015 Jun;16(6):360-74.
doi: 10.1038/nrm4002.

DNA Replication Origin Activation in Space and Time


DNA Replication Origin Activation in Space and Time

Michalis Fragkos et al. Nat Rev Mol Cell Biol. .


DNA replication begins with the assembly of pre-replication complexes (pre-RCs) at thousands of DNA replication origins during the G1 phase of the cell cycle. At the G1-S-phase transition, pre-RCs are converted into pre-initiation complexes, in which the replicative helicase is activated, leading to DNA unwinding and initiation of DNA synthesis. However, only a subset of origins are activated during any S phase. Recent insights into the mechanisms underlying this choice reveal how flexibility in origin usage and temporal activation are linked to chromosome structure and organization, cell growth and differentiation, and replication stress.

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