Hepatitis C Virus and Autoimmunity

Auto Immun Highlights. 2010 Jul 10;1(1):23-35. doi: 10.1007/s13317-010-0005-5. eCollection 2010 May.


Hepatitis C virus infection is associated with several extrahepatic manifestations. About 60% of patients infected with HCV develop at least one extrahepatic manifestation. The majority of these diseases seem to be triggered through autoimmune mechanisms, such as autoantibody production, autoreactive T cells and complex autoimmune mechanisms leading to systemic autoimmune disorders. In this review we categorize these diseases into three groups according to the main pathogenetic process involved, in particular B-cell-mediated, T-cell-mediated and complex autoimmune systemic diseases.

Keywords: Autoimmune mechanism; Extrahepatic manifestations; Hepatitis C; Lymphoma; Mixed cryoglobulinaemia vasculitis.

Publication types

  • Review