Turning up the heat on membrane fluidity

Weiwei Fan; Ronald M Evans

doi:10.1016/j.cell.2015.04.046

Turning up the heat on membrane fluidity

Cell. 2015 May 21;161(5):962-963. doi: 10.1016/j.cell.2015.04.046.

Authors

Weiwei Fan¹, Ronald M Evans²

Affiliations

¹ Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
² Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address: evans@salk.edu.

PMID: 26000475
DOI: 10.1016/j.cell.2015.04.046

Abstract

How do cells maintain the fluidity of cellular membrane in response to temperature fluctuation? In this issue of Cell, Ma et al. identify a regulatory circuit involving a heat-induced acyl-CoA dehydrogenase that controls the lipid saturation level and the fluidity of cellular membranes by transcriptionally regulating a lipid desaturase.

Publication types

Comment

MeSH terms

Acyl-CoA Dehydrogenase / metabolism*
Animals
Caenorhabditis elegans / physiology*
Caenorhabditis elegans Proteins / metabolism*
Fatty Acids / metabolism*

Substances

Caenorhabditis elegans Proteins
Fatty Acids
Acyl-CoA Dehydrogenase