Fluoxetine added to non-MAOI antidepressants converts nonresponders to responders: a preliminary report

J Clin Psychiatry. 1989 Dec;50(12):447-9.


Thirty depressed outpatients poorly responsive to various non-MAOI antidepressants had fluoxetine added to their regimens. Retrospective analysis revealed that 26 (86.7%) of the patients improved. Non-MAOI antidepressant treatment was withdrawn for 12 of the 26 responders; of these, 8 relapsed on fluoxetine treatment alone but recovered when treatment with the discontinued non-MAOI agent was restarted.

MeSH terms

  • Adult
  • Aged
  • Antidepressive Agents / therapeutic use*
  • Bipolar Disorder / drug therapy*
  • Depressive Disorder / drug therapy*
  • Drug Therapy, Combination
  • Female
  • Fluoxetine / therapeutic use*
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies


  • Antidepressive Agents
  • Fluoxetine