A meta-analysis on relationship of MAOB intron 13 polymorphisms, interactions with smoking/COMT H158L polymorphisms with the risk of PD

Int J Neurosci. 2016;126(5):400-7. doi: 10.3109/00207454.2015.1028057. Epub 2015 Jul 20.


Background: To date, many studies have examined the correlation between Monoamine oxidase B (MAOB) intron 13 A/G polymorphisms and the susceptibility to Parkinson's disease (PD). However, the results of these studies are inconclusive.

Methods: In order to confirm this correlation, a meta-analysis of 15 studies was performed and the dichotomous data are presented as odds ratios (ORs) and 95% confidence intervals (CIs).

Results: Carriers of the MAOB intron 13 A allele were more likely to have PD than carriers of the G allele in the Asian population (OR = 1.182, 95% CI = 1.012-1.380, p < 0.05). When combined with the COMT LL genotype, the MAOB intron 13 AA/(A) genotype increased the risk of PD susceptibility more than with the GA genotype or GG + GA/(G) genotype (AA/(A) vs. GG + GA/(G): OR = 1.610, 95% CI = 1.094-2.369; AA/(A) vs. GA: OR = 1.621, 95% CI = 1.004-2.619). Irrespective of whether individuals were in the AA/(A) genotype or GG + GA/(G) genotype subgroup, this meta-analysis indicated that smoking was a PD-preventive factor (AA/(A): OR = 1.823, 95% CI = 1.150-2.891; GG + GA/(G): OR = 2.245, 95% CI = 1.277-3.948).

Conclusion: The results of this meta-analysis suggest that people with the MAOB intron 13 A allele have an increased risk of PD in the Asian population, especially when combined with the COMT LL genotype.

Keywords: MAOB gene; Parkinson's disease; meta-analysis; polymorphism.

Publication types

  • Meta-Analysis

MeSH terms

  • Alleles
  • Catechol O-Methyltransferase / genetics*
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Introns*
  • Monoamine Oxidase / genetics*
  • Parkinson Disease / genetics*
  • Polymorphism, Single Nucleotide*
  • Protective Factors
  • Risk Factors
  • Smoking*


  • Monoamine Oxidase
  • COMT protein, human
  • Catechol O-Methyltransferase