Toward Whole-Transcriptome Editing with CRISPR-Cas9

Mol Cell. 2015 May 21;58(4):560-2. doi: 10.1016/j.molcel.2015.05.016.


Targeted regulation of gene expression holds huge promise for biomedical research. In a series of recent publications (Gilbert et al., 2014; Konermann et al., 2015; Zalatan et al., 2015), sophisticated, multiplex-compatible transcriptional activator systems based on the CRISPR-Cas9 technology and genome-scale libraries advance the field toward whole-transcriptome control.

Publication types

  • Comment

MeSH terms

  • CRISPR-Cas Systems / genetics*
  • Gene Expression*
  • Genetic Engineering / methods*
  • Genetic Techniques*
  • Genome, Human / genetics*
  • Humans
  • Melanoma / genetics*
  • Transcription, Genetic*
  • Transcriptional Activation / genetics*