2015 UK National Guideline on the management of non-gonococcal urethritis

Int J STD AIDS. 2016 Feb;27(2):85-96. doi: 10.1177/0956462415586675. Epub 2015 May 22.


We present the updated British Association for Sexual Health and HIV guideline for the management of non-gonococcal urethritis in men. This document includes a review of the current literature on its aetiology, diagnosis and management. In particular it highlights the emerging evidence that azithromycin 1 g may result in the development of antimicrobial resistance in Mycoplasma genitalium and that neither azithromycin 1 g nor doxycycline 100 mg twice daily for seven days achieves a cure rate of >90% for this micro-organism. Evidence-based diagnostic and management strategies for men presenting with symptoms suggestive of urethritis, those confirmed to have non-gonococcal urethritis and those with persistent symptoms following first-line treatment are detailed.

Keywords: Chlamydia trachomatis; Mycoplasma genitalium; NGU; NSU; Non-gonococcal urethritis; chlamydia; sexually transmitted infections; urethritis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / therapeutic use*
  • Azithromycin / therapeutic use
  • Chlamydia Infections / diagnosis
  • Chlamydia Infections / drug therapy*
  • Chlamydia trachomatis / isolation & purification
  • Disease Management
  • Doxycycline / therapeutic use
  • Drug Resistance, Bacterial
  • Fluoroquinolones / therapeutic use
  • Humans
  • Male
  • Metronidazole / therapeutic use
  • Moxifloxacin
  • Mycoplasma Infections / drug therapy*
  • Mycoplasma genitalium / isolation & purification
  • Practice Guidelines as Topic*
  • United Kingdom
  • Urethritis / diagnosis
  • Urethritis / drug therapy*
  • Urethritis / microbiology


  • Anti-Bacterial Agents
  • Fluoroquinolones
  • Metronidazole
  • Azithromycin
  • Doxycycline
  • Moxifloxacin