Vitamin D Is Significantly Associated With Total Testosterone and Sex Hormone-Binding Globulin in Malaysian Men

Aging Male. 2015;18(3):175-9. doi: 10.3109/13685538.2015.1034686. Epub 2015 May 25.

Abstract

Objective: Cross-sectional studies in the Caucasian population have shown a significant relationship between vitamin D and testosterone levels, but data in the Asian population are limited. This study aimed to determine the association between vitamin D and testosterone levels in Malaysian men.

Methods: Chinese and Malay men (n = 382) aged 20 years or above residing in the Klang Valley, Malaysia were recruited. Their fasting blood was collected for serum testosterone, sex hormone-binding globulin (SHBG) and 25-hydroxyvitamin D (25(OH)D) assays. Relationship between 25(OH)D and testosterone levels was analyzed using multiple regression analysis. Testosterone and SHBG levels among subjects with different vitamin D status were compared using univariate analysis. Confounders such as age, ethnicity and body mass index (BMI) were adjusted.

Results: 25(OH)D was significantly and positively associated with total testosterone and SHBG levels before and after adjustment for age and ethnicity (p < 0.05). Only association with SHBG remained significant after further adjustment for BMI (p < 0.05). Total testosterone and SHBG values displayed an increasing trend from subjects with vitamin D deficiency to those with optimal level (p < 0.05). The trend was attenuated after adjustment for BMI (p > 0.05).

Conclusion: 25(OH)D is significantly associated with total testosterone and SHBG in Malaysian men but this association is BMI-dependent.

Keywords: Men; sex hormone-binding globulin; testosterone; vitamin D.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Asian Continental Ancestry Group
  • Cross-Sectional Studies
  • Humans
  • Malaysia
  • Male
  • Middle Aged
  • Regression Analysis
  • Sex Hormone-Binding Globulin / analysis*
  • Testosterone / blood*
  • Vitamin D / analogs & derivatives*
  • Vitamin D / blood

Substances

  • Sex Hormone-Binding Globulin
  • Vitamin D
  • Testosterone
  • 25-hydroxyvitamin D