The evolution of IL-4 and IL-13 and their receptor subunits

Cytokine. 2015 Sep;75(1):8-13. doi: 10.1016/j.cyto.2015.04.012. Epub 2015 May 21.

Abstract

This review will outline what is known about the origins and evolution of type 2 cytokines and their receptors in vertebrates. It takes advantage of the recent advances made in gene identification from the many vertebrate genomes that have now been sequenced. It will also describe what functional studies have been performed to date, giving clues to the role of these molecules and signalling pathways in non-mammalian vertebrates.

Keywords: IL-4/13 molecules; IL-4/IL-13 evolution; IL-4R/IL-13R receptor evolution.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cytokines / physiology
  • Evolution, Molecular
  • Gene Expression Regulation*
  • Genome
  • Humans
  • Interleukin-13 / genetics
  • Interleukin-13 / physiology*
  • Interleukin-4 / genetics
  • Interleukin-4 / physiology*
  • Ligands
  • Molecular Sequence Data
  • Phylogeny
  • Protein Structure, Tertiary
  • Receptors, Cytokine / genetics
  • Receptors, Cytokine / physiology*
  • Sequence Homology, Amino Acid
  • Vertebrates

Substances

  • Cytokines
  • IL13 protein, human
  • IL4 protein, human
  • Interleukin-13
  • Ligands
  • Receptors, Cytokine
  • Interleukin-4