Enantioselective N-heterocyclic carbene-catalyzed synthesis of indenopyrones

Org Biomol Chem. 2015 Jun 28;13(24):6694-7. doi: 10.1039/c5ob00859j.

Abstract

The chiral N-heterocyclic carbene-catalyzed [4 + 2] cyclization of α-chloroaldehydes and arylidene indanediones was developed, giving the corresponding indenopyrones in good yields with high diastereoselectivities and enantioselectivities.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemical synthesis
  • Aldehydes / chemistry*
  • Catalysis
  • Cyclization
  • Halogenation
  • Heterocyclic Compounds / chemical synthesis
  • Heterocyclic Compounds / chemistry*
  • Indenes / chemical synthesis*
  • Indenes / chemistry
  • Methane / analogs & derivatives*
  • Methane / chemical synthesis
  • Methane / chemistry
  • Pyrones / chemical synthesis*
  • Pyrones / chemistry
  • Stereoisomerism

Substances

  • Aldehydes
  • Heterocyclic Compounds
  • Indenes
  • Pyrones
  • carbene
  • Methane