Abstract
Ex vivo gene therapy using retrievable encapsulated cellular implants is an effective strategy for the local and/or chronic delivery of therapeutic proteins. In particular, it is considered an innovative approach to modulate the activity of the immune system. Two recently proposed therapeutic schemes using genetically engineered encapsulated cells are discussed here: the chronic administration of monoclonal antibodies for passive immunization against neurodegenerative diseases and the local delivery of a cytokine as an adjuvant for anti-cancer vaccines.
Keywords:
Alzheimer’s disease; adjuvant; cancer vaccine; cellular implants; cytokine; encapsulation; genetic engineering; passive immunization; recombinant antibodies.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adjuvants, Immunologic / administration & dosage
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Alzheimer Disease / immunology
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Alzheimer Disease / therapy
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Animals
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Antibodies, Monoclonal / administration & dosage
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Cancer Vaccines / administration & dosage
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Cell- and Tissue-Based Therapy / methods*
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Cytokines / administration & dosage
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Genetic Engineering / methods
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Granulocyte-Macrophage Colony-Stimulating Factor / administration & dosage
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Humans
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Immune System
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Immunization, Passive / methods
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Immunotherapy / methods*
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Neoplasms / immunology
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Neoplasms / therapy*
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Neurodegenerative Diseases / immunology
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Neurodegenerative Diseases / therapy*
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Recombinant Proteins / administration & dosage
Substances
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Adjuvants, Immunologic
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Antibodies, Monoclonal
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Cancer Vaccines
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Cytokines
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Recombinant Proteins
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Granulocyte-Macrophage Colony-Stimulating Factor