Celiac disease, non-celiac gluten sensitivity and inflammatory bowel disease

Minerva Gastroenterol Dietol. 2015 Dec;61(4):267-71. Epub 2015 May 26.


Celiac disease (CD) and inflammatory bowel disease (IBD), such as Crohn's disease (CrD) and ulcerative colitis (UC), are chronic inflammatory condition of the gastro-intestinal tract. The prevalence of IBD in celiac patients has been reported as 5-10 times higher than in the general population. The possibility of the presence of CD in IBD should be considered in IBD patients with long-term iron deficiency anemia (IDA) not responsive to iron supplementation. Non-celiac gluten sensitivity (NCGS) is characterized by intestinal and extra intestinal symptoms due to the ingestion of gluten-containing food in subject without CD and/or wheat allergy. Patients with Crohn's disease and SR-NCGS were more significantly affected by joint pains compared to UC patients (50% versus 11.1%). In Crohn's patients, a higher percentage of fatigue (50% versus 38.9%) and headache (27.3% versus 22.2%) was evident. For the association between NCGS and IBD new studies are warranted and, at this moment, a gluten free diet (GFD) may be useful more in CrD than in UC.

Publication types

  • Review

MeSH terms

  • Celiac Disease / complications*
  • Celiac Disease / diagnosis
  • Food Hypersensitivity / complications*
  • Food Hypersensitivity / diagnosis
  • Glutens / adverse effects*
  • Humans
  • Inflammatory Bowel Diseases / complications*
  • Prevalence


  • Glutens