Comparative effects of red and white grapes on oxidative markers and lipidemic parameters in adult hypercholesterolemic humans

Food Funct. 2015 Jun;6(6):1992-8. doi: 10.1039/c5fo00100e.


The present study compared the effects of consuming red versus white whole grapes on oxidative and lipidemic indices in people with hypercholesterolemia. Sixty nine patients were randomized into three groups. The two treatment groups consumed 500 g of either Condori red grapes or Shahroodi white grapes daily for 8 weeks, and the third group served as a control. Plasma glucose, triacylglycerol (TG), cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), thiobarbituric acid reactive substances (TBARS) and total antioxidant capacity (TAC) were determined by colorimetric methods at baseline and at the end of the study. In addition, the polyphenol and fiber content of the two grape varieties was measured. TBARS was reduced in both study groups compared to the control group, and the reduction was greater in the group that consumed red grapes compared to the white grapes. TAC was increased significantly in both red and white grape consuming groups compared to the control group. Total cholesterol and LDL-C were decreased in the red grape group compared to the control group. No significant changes in fasting blood glucose, TG or HDL-C were observed among the groups. The results of this study suggest that consumption of the whole fruit of red grapes has more potent anti-oxidative and hypolipidemic effects compared to the white grapes in hyperlipidemic adult humans. Hence, the whole fruit of red grapes may be an excellent fruit choice not only to prevent oxidative stress related metabolic disorders but also cholesterol related cardiovascular diseases, particularly in hyperlipidemic adult humans.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antioxidants / analysis
  • Antioxidants / therapeutic use
  • Biomarkers / blood
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • Dietary Fiber / analysis
  • Dietary Fiber / therapeutic use
  • Female
  • Flavonoids / analysis
  • Flavonoids / therapeutic use
  • Fruit* / chemistry
  • Fruit* / metabolism
  • Functional Food* / analysis
  • Humans
  • Hypercholesterolemia / blood
  • Hypercholesterolemia / diet therapy*
  • Iran
  • Lipid Peroxidation*
  • Male
  • Middle Aged
  • Oxidative Stress*
  • Pigments, Biological / biosynthesis
  • Seeds* / chemistry
  • Species Specificity
  • Thiobarbituric Acid Reactive Substances / analysis
  • Vitis* / chemistry
  • Vitis* / metabolism


  • Antioxidants
  • Biomarkers
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Dietary Fiber
  • Flavonoids
  • Pigments, Biological
  • Thiobarbituric Acid Reactive Substances