Review article: The pharmacokinetics and pharmacodynamics of drugs used in inflammatory bowel disease treatment

E G Quetglas; A Armuzzi; S Wigge; G Fiorino; L Barnscheid; M Froelich; Silvio Danese

doi:10.1007/s00228-015-1862-7

Review article: The pharmacokinetics and pharmacodynamics of drugs used in inflammatory bowel disease treatment

Eur J Clin Pharmacol. 2015 Jul;71(7):773-99. doi: 10.1007/s00228-015-1862-7. Epub 2015 May 27.

Authors

E G Quetglas¹, A Armuzzi, S Wigge, G Fiorino, L Barnscheid, M Froelich, Silvio Danese

Affiliation

¹ Project Strategy & Science, Grünenthal GmbH, Aachen, Germany.

PMID: 26008212
DOI: 10.1007/s00228-015-1862-7

Abstract

Background: The following review is a compilation of the recent advances and knowledge on the behaviour of the most frequently used compounds to treat inflammatory bowel disease in an organism.

Results: It considers clinical aspects of each entity and the pharmacokinetic/pharmacodynamic relationship supported by the use of plasma monitoring, tissue concentrations, and certain aspects derived from pharmacogenetics.

Publication types

Review

MeSH terms

Animals
Anti-Inflammatory Agents / adverse effects
Anti-Inflammatory Agents / pharmacokinetics*
Anti-Inflammatory Agents / therapeutic use*
Colitis, Ulcerative / diagnosis
Colitis, Ulcerative / drug therapy*
Colitis, Ulcerative / immunology
Crohn Disease / diagnosis
Crohn Disease / drug therapy*
Crohn Disease / immunology
Drug Monitoring
Gastrointestinal Agents / adverse effects
Gastrointestinal Agents / pharmacokinetics*
Gastrointestinal Agents / therapeutic use*
Humans
Pharmacogenetics
Remission Induction
Treatment Outcome

Substances

Anti-Inflammatory Agents
Gastrointestinal Agents