Comparison of the Effect of Pre-operative Single Oral Dose of Tramadol and Famotidine on Gastric Secretions pH and Volume in Patients Scheduled for Laparoscopic Cholecystectomy

J Coll Physicians Surg Pak. 2015 May;25(5):320-3.


Objective: To evaluate and compare the effects of pre-operative single oral dose of tramadol and famotidine on gastric secretions pH and volume in patients electively scheduled for laparoscopic cholecystectomy.

Study design: Randomized control trial.

Place and duration of study: Department of Anaesthesia, King Saud University Riyadh, Saudi Arabia, from August 2011 to June 2013.

Methodology: Ninety adult, ASA-I and II patients scheduled for laparoscopic cholecystectomy were included in the study. Patients were randomly assigned to receive pre-operatively either placebo (Group-C, n=30), oral tramadol 100 mg (Group-T, n=30) or famotidine 40 mg (Group-F, n=30). After induction of general anaesthesia, gastric fluid was aspirated through orogastric tube. The gastric secretions volume and pH was measured using pH meter.

Results: There was no statistically difference between groups in age, weight and gender. The gastric secretions mean pH was 2.06 ± 0.22,2.04 ± 0.20, 5.79 ± 0.77 and volume was 0.59 ± 0.17, 0.59 ± 0.14 and 0.28 ± 0.16 ml/kg in Group-C, Group-T and Group-F respectively. There was a significant statistical difference in the mean pH values between Group-C vs. Group-F (p < 0.001) and Group-T vs. Group-F (p < 0.001). Statistically significant difference was also found in the mean gastric secretions volume between Group - C vs. Group-F (p < 0.001) and Group-T vs. Group-F (p < 0.001). There was no significant difference in the mean gastric fluid pH values (p=0.99) and mean gastric secretions volume (p=0.99) between Group-T and Group-C.

Conclusion: As compared to famotidine, pre-operative single oral dose of tramadol was unable to elevate the desired level of gastric fluid pH (> 2.5) and decrease in gastric secretions volume (< 0.4 ml/kg).

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Adult
  • Aged
  • Analgesics, Opioid / administration & dosage
  • Analgesics, Opioid / pharmacology*
  • Anesthesia, General
  • Anti-Ulcer Agents / administration & dosage
  • Anti-Ulcer Agents / pharmacology*
  • Cholecystectomy, Laparoscopic*
  • Elective Surgical Procedures
  • Famotidine / administration & dosage
  • Famotidine / pharmacology*
  • Female
  • Gastric Acid / metabolism*
  • Gastric Juice / drug effects*
  • Gastric Mucosa / drug effects
  • Gastric Mucosa / metabolism
  • Humans
  • Hydrogen-Ion Concentration
  • Male
  • Middle Aged
  • Pain, Postoperative / prevention & control
  • Perioperative Care
  • Saudi Arabia
  • Tramadol / administration & dosage
  • Tramadol / pharmacology*
  • Treatment Outcome


  • Analgesics, Opioid
  • Anti-Ulcer Agents
  • Tramadol
  • Famotidine