Transfusion Strategy for Acute Upper Gastrointestinal Bleeding

CJEM. 2015 Sep;17(5):582-5. doi: 10.1017/cem.2014.76. Epub 2015 Apr 10.

Abstract

Clinical question Does a hemoglobin transfusion threshold of 70 g/L yield better patient outcomes than a threshold of 90 g/L in patients with acute upper gastrointestinal bleeding? Article chosen Villanueva C, Colomo A, Bosch A, et al. Transfusion strategies for acute upper gastrointestinal bleeding. N Engl J Med 2013;368(1):11-21. Study objectives The authors of this study measured mortality, from any cause, within the first 45 days, in patients with acute upper gastrointestinal bleeding, who were managed with a hemoglobin threshold for red cell transfusion of either 70 g/L or 90 g/L. The secondary outcome measures included rate of further bleeding and rate of adverse events.

Keywords: bleeding; gastrointestinal; transfusion.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Acute Disease
  • Adolescent
  • Blood Transfusion / standards*
  • Female
  • Gastrointestinal Hemorrhage / mortality
  • Gastrointestinal Hemorrhage / therapy*
  • Humans
  • Male
  • Practice Guidelines as Topic*
  • Retrospective Studies
  • Survival Rate / trends