Anti-Inflammatory Activity of Polysaccharide Fraction of Curcuma longa Extract (NR-INF-02)

Antiinflamm Antiallergy Agents Med Chem. 2015;14(1):53-62. doi: 10.2174/1871523014666150407150533.

Abstract

The aim of the study was to investigate the safety and anti-inflammatory effects of polysaccharide fraction (F1) of Curcuma longa extract (NR-INF-02) in classical rodent models of inflammation. F1 was evaluated for its acute oral toxicity and found to be safe upto 5000 mg/kg body weight in rats. The anti-inflammatory activity of F1 was evaluated in acute (carrageenan - induced paw edema; xylene - induced ear edema) and chronic (cotton pellet - induced granuloma) models of inflammation. The results of the study demonstrated that F1 significantly (p ≤ 0.05) inhibited carrageenan-induced paw edema at 1 h and 3 h at doses of 11.25, 22.5 and 45 mg/kg body weight in rats. Also, F1 at doses of 15.75, 31.5 and 63 mg/kg significantly inhibited the xylene induced ear edema in mice. In a chronic model, F1 at 11.25, 22.5 and 45 mg/kg doses produced significant reduction of wet and dry weights of cotton pellets in rats. Overall results indicated that F1 of NR-INF-02 significantly attenuated acute and chronic inflammation in rodent models. This study emphasizes on the importance of Curcuma longa polysaccharide's role in acute and chronic inflammation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / administration & dosage*
  • Carrageenan / administration & dosage
  • Chemical Fractionation
  • Curcuma*
  • Disease Models, Animal
  • Edema / chemically induced
  • Edema / prevention & control*
  • Female
  • Granuloma / prevention & control*
  • Humans
  • Male
  • Mice
  • Plant Extracts / administration & dosage*
  • Plant Extracts / adverse effects
  • Polysaccharides
  • Rats
  • Rats, Wistar
  • Xylenes / administration & dosage

Substances

  • Anti-Inflammatory Agents
  • Plant Extracts
  • Polysaccharides
  • Xylenes
  • Carrageenan