In Vitro and In Vivo Studies of the Biological Effects of Bioceramic (a Material of Emitting High Performance Far-Infrared Ray) Irradiation

Chin J Physiol. 2015 Jun 30;58(3):147-55. doi: 10.4077/CJP.2015.BAD294.


Bioceramic is a material that emits high performance far-infrared ray, and possess physical, chemical and biological characteristics on irradiation of water, particularly to in reducing the size of water clusters, weakening of the hydrogen bonds of water molecules and other effects on physical and chemical properties of water. In this review paper, we summarized the in vivo and in vitro biological effects of Biocermaic, and included previous published data on nitric oxide, calmodulin induction on cells, effects of bioceramic on intracellular heat shock protein and intracellular nitric oxide contents of melanoma cells, antioxidant effects of Bioceramic on cells and plants under H₂O₂-mediated oxidative stress, effects on anti-oxidative stress of myoblast cells and on preventing fatigue of amphibian skeletal muscle during exercise, anti-inflammatory and pain relief mechanism, effects on the chondrosarcoma cell line with prostaglandin E2 production, effects on the rabbit with inflammatory arthritis by injection of lipopolysaccharides under monitoring by positron emission tomography scan, effects on psychological stress-conditioned elevated heart rate, blood pressure and oxidative stress-suppressed cardiac contractility, and protective effects of non-ionized radiation against oxidative stress on human breast epithelial cell. We anticipate that the present work will benefit medical applications.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antioxidants / pharmacology
  • Ceramics / pharmacology*
  • Female
  • HSP70 Heat-Shock Proteins / biosynthesis
  • Humans
  • Hydrogen-Ion Concentration
  • In Vitro Techniques
  • Infrared Rays*
  • MCF-7 Cells
  • Macrophages / metabolism
  • Mice
  • Nitric Oxide / biosynthesis
  • Physical Conditioning, Animal / physiology
  • Positron-Emission Tomography
  • Rabbits
  • Radiation-Protective Agents / pharmacology


  • Antioxidants
  • HSP70 Heat-Shock Proteins
  • Radiation-Protective Agents
  • Nitric Oxide