Activity of Imipenem with Relebactam against Gram-Negative Pathogens from New York City

Antimicrob Agents Chemother. 2015 Aug;59(8):5029-31. doi: 10.1128/AAC.00830-15. Epub 2015 May 26.

Abstract

Imipenem with relebactam was active against Escherichia coli, Klebsiella pneumoniae, and Enterobacter spp., including K. pneumoniae carbapenemase (KPC)-producing isolates. Loss of OmpK36 in KPC-producing K. pneumoniae isolates affected the susceptibility of this combination. Enhanced activity was evident against Pseudomonas aeruginosa, including isolates with depressed oprD and increased ampC expression. However, the addition of relebactam to imipenem did not provide added benefit against Acinetobacter baumannii. The combination of imipenem with relebactam demonstrated activity against KPC-producing Enterobacteriaceae and multidrug-resistant P. aeruginosa.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acinetobacter baumannii / drug effects
  • Acinetobacter baumannii / genetics*
  • Acinetobacter baumannii / isolation & purification
  • Anti-Bacterial Agents / pharmacology
  • Azabicyclo Compounds / pharmacology*
  • Bacterial Proteins / antagonists & inhibitors
  • Drug Resistance, Multiple, Bacterial / genetics
  • Drug Therapy, Combination
  • Enterobacteriaceae / drug effects
  • Enterobacteriaceae / genetics*
  • Enterobacteriaceae / isolation & purification
  • Humans
  • Imipenem / pharmacology*
  • Microbial Sensitivity Tests
  • New York City
  • Pseudomonas aeruginosa / drug effects
  • Pseudomonas aeruginosa / genetics*
  • Pseudomonas aeruginosa / isolation & purification
  • beta-Lactamase Inhibitors / pharmacology*
  • beta-Lactamases

Substances

  • Anti-Bacterial Agents
  • Azabicyclo Compounds
  • Bacterial Proteins
  • beta-Lactamase Inhibitors
  • Imipenem
  • beta-Lactamases
  • carbapenemase
  • relebactam