Effects of a high-protein/low-carbohydrate versus a standard hypocaloric diet on adipocytokine levels and cardiovascular risk factors during 9 months, role of rs6923761 gene variant of glucagon-like peptide 1 receptor

J Endocrinol Invest. 2015 Nov;38(11):1183-9. doi: 10.1007/s40618-015-0304-9. Epub 2015 May 27.


Background: The role of GLP-1 R variants on body weight response after dietary intervention is unclear.

Objective: The aim was to investigate the role of this polymorphism on cardiovascular risk factors, adipokine levels and weight loss secondary to a high-protein/low-carbohydrate vs. standard hypocaloric diets during 9 months.

Design: 211 obese subjects were randomly allocated to one of these two diets for a period of 9 months; diet HP (high protein/low carbohydrate) and diet S (standard).

Results: Ninety-four patients (44.5%) had the genotype GG (wild group) and 117 (55.5%) patients had the next genotypes; GA (89 patients, 42.2%) or AA (28 patients, 13.3%) (mutant group). With both diets and in both genotype groups, body mass index, weight, fat mass, waist circumference and systolic blood pressure decreased. Anthropometric parameters were higher in non-A allele carriers than A allele carriers. With diet HP in both genotypes, LDL cholesterol, total cholesterol, leptin, insulin levels and HOMA-R decreased. With the diet S and only in wild genotype, the same parameters decreased, too.

Conclusion: Our data showed a lack of association of rs6923761 GLP-1 R polymorphism with weight loss. Better anthropometric parameters in obese subjects with the mutant allele (A) of rs6923761 GLP-1 R polymorphism were observed. Total cholesterol, LDL cholesterol, insulin levels and HOMA-R decreased in all patients with both diets, although A allele carriers treated with standard diet did not show these changes.

Keywords: Glucagon-like peptide 1 receptor; Hypocaloric diet; Weight loss; rs6923761.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adipokines / blood*
  • Adult
  • Cardiovascular Diseases* / blood
  • Cardiovascular Diseases* / diet therapy
  • Cardiovascular Diseases* / genetics
  • Diet, Carbohydrate-Restricted / methods
  • Diet, Reducing / methods*
  • Female
  • Genotype
  • Glucagon-Like Peptide-1 Receptor / genetics*
  • Humans
  • Male
  • Middle Aged
  • Obesity* / blood
  • Obesity* / diet therapy
  • Obesity* / genetics
  • Polymorphism, Genetic
  • Risk Factors
  • Time Factors
  • Treatment Outcome
  • Weight Loss* / genetics
  • Weight Loss* / physiology


  • Adipokines
  • GLP1R protein, human
  • Glucagon-Like Peptide-1 Receptor