[Anxiolytic and antidepressant effects of 3-oxypiridine and succinic acid derivatives in alloxan diabetes]

Ross Fiziol Zh Im I M Sechenova. 2015 Mar;101(3):258-67.
[Article in Russian]

Abstract

The effects of 3-oxypyridine and succinic acid derivatives (emoxipine, reamberin and mexidol) on affective disorders in rats with alloxan diabetes were studied. The efficiency of emoxipine, reamberin and mexidol was compared to alpha-lipoic acid, which is considered a "golden standard" in treatment of diabetic neuropathies. Emoxipine, reamberin and mexidol after seven administrations in single doses, that are equivalent to therapeutic range in humans, corrected the anxiety-depressive disorders in rats with alloxan diabetes. Unlike reamberin and alpha-lipoic acid, emoxipine and mexidol corrected the affective status concurrently with the decrease in hyperglycemia. At the same time, emoxipine outperformed mexidol in tranquilizing action (in maximal doses) but yielded mexidol in the antidepressant effect (in minimal doses).

MeSH terms

  • Animals
  • Anti-Anxiety Agents / administration & dosage*
  • Anxiety / drug therapy*
  • Anxiety / physiopathology
  • Depression / drug therapy*
  • Depression / physiopathology
  • Diabetes Mellitus, Experimental / drug therapy
  • Diabetes Mellitus, Experimental / physiopathology
  • Humans
  • Hyperglycemia / drug therapy
  • Meglumine / administration & dosage
  • Meglumine / analogs & derivatives
  • Picolines / administration & dosage
  • Pyridines / administration & dosage*
  • Rats
  • Succinates / administration & dosage
  • Succinic Acid / administration & dosage*
  • Thioctic Acid / administration & dosage

Substances

  • 3-oxypyridine
  • Anti-Anxiety Agents
  • Picolines
  • Pyridines
  • Reamberin
  • Succinates
  • emoxypine succinate
  • Meglumine
  • Thioctic Acid
  • Succinic Acid
  • 6-methyl-2-ethyl-3-hydroxypyridine