Optimization and application of reflective LSPR optical fiber biosensors based on silver nanoparticles

Jiangping Chen; Se Shi; Rongxin Su; Wei Qi; Renliang Huang; Mengfan Wang; Libing Wang; Zhimin He

doi:10.3390/s150612205

Optimization and application of reflective LSPR optical fiber biosensors based on silver nanoparticles

Sensors (Basel). 2015 May 26;15(6):12205-17. doi: 10.3390/s150612205.

Authors

Jiangping Chen¹, Se Shi², Rongxin Su^{3

4}, Wei Qi^{5

6}, Renliang Huang⁷, Mengfan Wang⁸, Libing Wang⁹, Zhimin He¹⁰

Affiliations

¹ State Key Laboratory of Chemical Engineering, Tianjin Key Laboratory of Membrane Science and Desalination Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China. cjpjm@126.com.
² State Key Laboratory of Chemical Engineering, Tianjin Key Laboratory of Membrane Science and Desalination Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China. shise@tju.edu.cn.
³ State Key Laboratory of Chemical Engineering, Tianjin Key Laboratory of Membrane Science and Desalination Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China. surx@tju.edu.cn.
⁴ Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, China. surx@tju.edu.cn.
⁵ State Key Laboratory of Chemical Engineering, Tianjin Key Laboratory of Membrane Science and Desalination Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China. qiwei@tju.edu.cn.
⁶ Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, China. qiwei@tju.edu.cn.
⁷ School of Environmental Science and Engineering, Tianjin University, Tianjin 300072, China. tjuhrl@tju.edu.cn.
⁸ State Key Laboratory of Chemical Engineering, Tianjin Key Laboratory of Membrane Science and Desalination Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China. mwang@tju.edu.cn.
⁹ State Key Laboratory of Chemical Engineering, Tianjin Key Laboratory of Membrane Science and Desalination Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China. wanglb1@163.com.
¹⁰ State Key Laboratory of Chemical Engineering, Tianjin Key Laboratory of Membrane Science and Desalination Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China. enzyme@tju.edu.cn.

Abstract

In this study, we developed a reflective localized surface plasmon resonance (LSPR) optical fiber sensor, based on silver nanoparticles (Ag NPs). To enhance the sensitivity of the LSPR optical sensor, two key parameters were optimized, the length of the sensing area and the coating time of the Ag NPs. A sensing length of 1.5 cm and a 1-h coating time proved to be suitable conditions to produce highly sensitive sensors for biosensing. The optimized sensor has a high refractive index sensitivity of 387 nm/RIU, which is much higher than that of other reported individual silver nanoparticles in solutions. Moreover, the sensor was further modified with antigen to act as a biosensor. Distinctive wavelength shifts were found after each surface modification step. In addition, the reflective LSPR optical fiber sensor has high reproducibility and stability.

Keywords: biosensors; localized surface plasmon resonance; optical fiber; silver nanoparticles.