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. Apr-Jun 2015;18(2):154-6.
doi: 10.4103/0972-2327.150622.

Lhermitte's Sign: The Current Status

Free PMC article

Lhermitte's Sign: The Current Status

Supreet Khare et al. Ann Indian Acad Neurol. .
Free PMC article


Lhermitte's sign was described by Marie and Chatelin and named after Jean Lhermitte. This sign is mostly described as an electric shock like condition by some patients of multiple sclerosis. This sensation occurs when the neck is moved in a wrong way or rather flexed. It can also travel down to the spine, arms, and legs, and sometimes the trunk. Demyelination and hyperexcitability are the main pathophysiological reasons depicted for the Lhermitte's sign. Other causes for Lhermitte's sign include transverse myelitis, behçet's disease, trauma, etc. This article reviews the Lhermitte's sign, its history, and its etiopathophysiology. Very few studies are available on Lermitte's sign and more research need to be done on the same to ensure its sensitivity and specificity.

Keywords: Demyelination; Lhermitte's sign; shock like sensation.

Conflict of interest statement

Conflict of Interest: None declared.

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    1. Walton J.N., John N. (MD), editors. 8th ed. Oxford: Oxford University Press; 1977. Brain's Diseases of the Nervous System. pp. xvi + 1277:526-568.
    1. Studer G, Linsenmeier C, Riesterer O, Najafi Y, Brown M, Yousefi B, et al. Late term tolerance in head neck cancer patients irradiated in the IMRT era. Radiat Oncol. 2013;8:259. - PMC - PubMed
    1. Lim DC, Gagnon PJ, Meranvil S, Kaurin D, Lipp L, Holland JM. Lhermitte's sign developing after imrt for head and neck cancer. Int J Otolaryngol 2010. 2010 907960. - PMC - PubMed
    1. Pak D, Vineberg K, Feng F, Ten Haken RK, Eisbruch A. Lhermitte sign after chemo-IMRT of head-and-neck cancer: Incidence, doses, and potential mechanisms. Int J Radiat Oncol Biol Phys. 2012;83:1528–33. - PMC - PubMed
    1. Karacostas D, Artemis N, Bairactaris C, Tsitourides I, Milonas I. Cobalamin deficiency: MRI detection of posterior columns involvement and posttreatment resolution. J Neuroimaging. 1998;8:171–3. - PubMed