Surgical Management of Barrett's Esophagus

Gastroenterol Clin North Am. 2015 Jun;44(2):459-71. doi: 10.1016/j.gtc.2015.02.013. Epub 2015 Mar 24.


Patients with gastroesophageal reflux disease and Barrett's esophagus can be a management challenge for the treating physician or surgeon. The goals of therapy include relief of reflux symptoms, induction of histologic regression, and prevention of progression of intestinal metaplasia to dysplasia or invasive carcinoma. Antireflux surgery is effective at achieving these end points, although ongoing follow-up and endoscopic surveillance are essential. In cases of dysplasia or early esophageal neoplasia associated with Barrett's esophagus, endoscopic resection and ablation have supplanted esophagectomy as the standard of care in most cases. Esophageal resection continues to have a role, however, in a minority of appropriately selected candidates.

Keywords: Antireflux surgery; Barrett’s esophagus; Esophagectomy; Intramucosal adenocarcinoma; Nissen fundoplication.

Publication types

  • Review

MeSH terms

  • Ablation Techniques
  • Adenocarcinoma / surgery*
  • Barrett Esophagus / drug therapy
  • Barrett Esophagus / etiology*
  • Barrett Esophagus / pathology
  • Barrett Esophagus / surgery*
  • Esophageal Neoplasms / surgery*
  • Esophageal pH Monitoring
  • Esophagectomy
  • Esophagoscopy
  • Fundoplication*
  • Gastroesophageal Reflux / complications
  • Gastroesophageal Reflux / drug therapy
  • Gastroesophageal Reflux / physiopathology
  • Gastroesophageal Reflux / surgery*
  • Histamine H2 Antagonists / therapeutic use
  • Humans
  • Mucous Membrane / surgery
  • Postoperative Care
  • Proton Pump Inhibitors / therapeutic use
  • Recurrence


  • Histamine H2 Antagonists
  • Proton Pump Inhibitors