Postoperative Deep Infection After Cemented Versus Cementless Total Hip Arthroplasty: A Meta-Analysis

J Arthroplasty. 2015 Oct;30(10):1823-7. doi: 10.1016/j.arth.2015.04.041. Epub 2015 May 7.

Abstract

Periprosthetic joint infection (PJI) is a serious complication of total hip arthroplasty (THA). The objective of this meta-analysis was to compare the PJI rate between cemented and cementless THAs. Eight clinical studies (2 randomized controlled trials and 6 observational studies) were available for the analysis. Meta-analysis (with a fixed-effects model) and subgroup analysis were performed by research design and meta-regression was performed by continuous moderator. The overall incidence of PJI was 0.4% (357/84,200). The incidence was 0.5% (310/67,531) in cemented group, and 0.3% (47/16,669) in cementless group (P=0.008). The meta-analysis revealed that the use of cement in THA was associated with an increased risk of PJI (odds ratio 1.53; 95% confidence interval 1.120 to 2.100; P=0.008).

Keywords: cemented; cementless; infection; meta-analysis; total hip arthroplasty.

Publication types

  • Meta-Analysis
  • Review

MeSH terms

  • Arthritis, Infectious
  • Arthroplasty, Replacement, Hip / adverse effects*
  • Bone Cements / therapeutic use*
  • Hip Prosthesis / adverse effects*
  • Humans
  • Incidence
  • Observational Studies as Topic
  • Odds Ratio
  • Postoperative Complications / etiology
  • Prosthesis-Related Infections / diagnosis*
  • Prosthesis-Related Infections / epidemiology
  • Randomized Controlled Trials as Topic
  • Regression Analysis

Substances

  • Bone Cements