Biogenesis of Endosome-Derived Transport Carriers

Cell Mol Life Sci. 2015 Sep;72(18):3441-3455. doi: 10.1007/s00018-015-1935-x. Epub 2015 May 29.


Sorting of macromolecules within the endosomal system is vital for physiological control of nutrient homeostasis, cell motility, and proteostasis. Trafficking routes that export macromolecules from the endosome via vesicle and tubule transport carriers constitute plasma membrane recycling and retrograde endosome-to-Golgi pathways. Proteins of the sorting nexin family have been discovered to function at nearly every step of endosomal transport carrier biogenesis and it is becoming increasingly clear that they form the core machineries of cargo-specific transport pathways that are closely integrated with cellular physiology. Here, we summarize recent progress in elucidating the pathways that mediate the biogenesis of endosome-derived transport carriers.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biological Transport / physiology*
  • Cell Membrane / metabolism
  • Cell Membrane / physiology
  • Endosomes / metabolism*
  • Endosomes / physiology*
  • Golgi Apparatus / metabolism
  • Golgi Apparatus / physiology
  • Humans
  • Vesicular Transport Proteins / metabolism*


  • Vesicular Transport Proteins