Inhibition of male sexual behavior by serotonin application in the medial preoptic area

Physiol Behav. 1989 Aug;46(2):327-30. doi: 10.1016/0031-9384(89)90275-8.


The study investigated the possible involvement of serotonin in the medial preoptic area in the regulation of sexual behavior of male rats. Injection of serotonin in the medial preoptic area resulted in an inhibition, whereas cyproheptadine (a serotonin antagonist) produced a slight facilitation, of male sexual behavior.

MeSH terms

  • Animals
  • Cyproheptadine / pharmacology*
  • Male
  • Preoptic Area / drug effects
  • Preoptic Area / physiology*
  • Rats
  • Rats, Inbred Strains
  • Serotonin / pharmacology*
  • Sexual Behavior, Animal / drug effects*


  • Cyproheptadine
  • Serotonin