Basic biology and therapeutic implications of lncRNA

Adv Drug Deliv Rev. 2015 Jun 29:87:15-24. doi: 10.1016/j.addr.2015.05.012. Epub 2015 May 27.


Long non-coding RNAs (lncRNA), a class of non-coding RNA molecules recently identified largely due to the efforts of FANTOM, and later GENCODE and ENCODE consortia, have been a subject of intense investigation in the past decade. Extensive efforts to get deeper understanding of lncRNA biology have yielded evidence of their diverse structural and regulatory roles in protecting chromosome integrity, maintaining genomic architecture, X chromosome inactivation, imprinting, transcription, translation and epigenetic regulation. Here we will briefly review the recent studies in the field of lncRNA biology focusing mostly on mammalian species and discuss their therapeutic implications.

Keywords: AntagoNAT; Epigenetic regulation; Imprinting; Natural antisense transcripts; Paraspeckles; Telomeres; lincRNA; vlincRNA.

Publication types

  • Review

MeSH terms

  • Animals
  • Chromosomal Instability
  • Epigenesis, Genetic
  • Evolution, Molecular
  • Gene Expression Regulation / drug effects
  • Gene Expression Regulation / genetics*
  • Genetic Diseases, Inborn / diagnosis
  • Genetic Diseases, Inborn / genetics
  • Genetic Diseases, Inborn / therapy
  • Humans
  • Neoplasms / diagnosis
  • Neoplasms / genetics
  • Neoplasms / therapy
  • Oligonucleotides, Antisense / administration & dosage
  • Oligonucleotides, Antisense / therapeutic use
  • RNA Processing, Post-Transcriptional
  • RNA, Long Noncoding / blood
  • RNA, Long Noncoding / genetics*
  • RNA, Long Noncoding / urine
  • Species Specificity
  • Telomere / genetics


  • Oligonucleotides, Antisense
  • RNA, Long Noncoding