(Hyper)tension release by N-terminal acetylation

Henriette Aksnes; Adrian Drazic; Thomas Arnesen

doi:10.1016/j.tibs.2015.05.003

(Hyper)tension release by N-terminal acetylation

Trends Biochem Sci. 2015 Aug;40(8):422-4. doi: 10.1016/j.tibs.2015.05.003. Epub 2015 May 28.

Authors

Henriette Aksnes¹, Adrian Drazic¹, Thomas Arnesen²

Affiliations

¹ Department of Molecular Biology, University of Bergen, N-5020 Bergen, Norway.
² Department of Molecular Biology, University of Bergen, N-5020 Bergen, Norway; Department of Surgery, Haukeland University Hospital, N-5021 Bergen, Norway. Electronic address: thomas.arnesen@uib.no.

PMID: 26027460
DOI: 10.1016/j.tibs.2015.05.003

Abstract

A recent study links N-terminal acetylation and N-end rule degradation to blood pressure regulation. N-terminal mutants of Rgs2, a key G-protein regulator, are differentially processed by N-terminal acetyltransferases and the two branches of the N-end rule pathway. This leads to an imbalance in the signaling governing blood pressure.

Keywords: G-protein signaling; N-end rule; N-terminal acetylation; Rgs2; blood pressure regulation; protein degradation.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Humans
RGS Proteins / metabolism*

Substances

RGS Proteins