Aerobic glycolysis: beyond proliferation

Front Immunol. 2015 May 15;6:227. doi: 10.3389/fimmu.2015.00227. eCollection 2015.


Aerobic glycolysis has been generally associated with cancer cell proliferation, but fascinating and novel data show that it is also coupled to a series of further cellular functions. In this Mini Review, we will discuss some recent findings to illustrate newly defined roles for this process, in particular in non-malignant cells, supporting the idea that metabolism can be considered as an integral part of cellular signaling. Consequently, metabolism should be regarded as a plastic and highly dynamic determinant of a wide range of cellular specific functions.

Keywords: aerobic glycolysis; cellular signalling; immunometabolism; non-malignant cells; proliferation.

Publication types

  • Review