Treatment of a medial collateral ligament sprain using prolotherapy: a case study

Altern Ther Health Med. 2015 Jul-Aug;21(4):68-71.


Prolotherapy is effective in treating refractory tendinopathies, but inadequate clinical evidence exists to recommend its use as a treatment for acute or chronic, medial collateral ligament (MCL) injuries. The current case study documents an illustrative case of a rugby player who had a grade 2 sprain of the MCL and shows the clinical and radiological outcomes following injections of 15% dextrose combined with 0.2% lidocaine. In his case, the prolotherapy, together with an exercise therapy, lasted 3 wk. At the end of the 3 wk, the patient was pain free, with a full range of motion (ROM), and he was able to perform all rugby-specific movements. The mean duration for recovery with conservative treatment of isolated, complete tears of the MCL is normally 4-8 wk.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Collateral Ligaments / injuries*
  • Collateral Ligaments / physiopathology
  • Complementary Therapies / methods*
  • Exercise Therapy
  • Glucose / administration & dosage
  • Humans
  • Injections, Intra-Articular
  • Knee Injuries / physiopathology
  • Knee Injuries / therapy*
  • Lidocaine / administration & dosage
  • Male
  • Sprains and Strains / physiopathology
  • Sprains and Strains / therapy*
  • Young Adult


  • Lidocaine
  • Glucose