Abstract
The analysis of intestinal differentiation transcription factor CDX2 in the gastric mucosa biopsies has been carried out. It was established that CDX2 by itself promoter activation pathway can obtain intestinal phenotype for gastric mucosa cells. The loss of CDX2 expression in the nuclei of metaplastic epithelium may serve as a predictor of gastric mucosa malignization.
MeSH terms
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Biomarkers / metabolism
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CDX2 Transcription Factor
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Cell Nucleus / genetics
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Cell Nucleus / metabolism
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Cell Transdifferentiation / genetics
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Cell Transformation, Neoplastic / genetics*
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Cell Transformation, Neoplastic / metabolism
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Cell Transformation, Neoplastic / pathology
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Epithelial Cells / metabolism
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Epithelial Cells / pathology
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Female
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Gastric Mucosa / metabolism
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Gastric Mucosa / pathology*
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Gene Expression Regulation, Neoplastic*
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Helicobacter Infections / genetics*
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Helicobacter Infections / metabolism
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Helicobacter Infections / microbiology
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Helicobacter Infections / pathology
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Helicobacter pylori / physiology
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Homeodomain Proteins / genetics*
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Homeodomain Proteins / metabolism
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Humans
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Intestinal Mucosa / metabolism
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Intestinal Mucosa / pathology
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Male
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Metaplasia / genetics
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Metaplasia / metabolism
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Metaplasia / pathology
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Middle Aged
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Phenotype
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Promoter Regions, Genetic
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Stomach Neoplasms / genetics*
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Stomach Neoplasms / metabolism
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Stomach Neoplasms / pathology
Substances
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Biomarkers
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CDX2 Transcription Factor
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CDX2 protein, human
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Homeodomain Proteins