Proliferative changes in the prostate

Toxicol Appl Pharmacol. 1989 Dec;101(3):499-509. doi: 10.1016/0041-008x(89)90198-1.


The prostate of the rat has several lobes which have variable responsiveness to estrogens and testosterone. Testosterone is a major stimulant of cell proliferation in the prostate. Chemical carcinogenesis models in the rat prostate have taken advantage of administering the carcinogen during the peak proliferative period following testosterone administration with subsequent testosterone administered to continue the proliferative stimulus. Invasive adenocarcinomas of the prostate have been induced utilizing such methods.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aging
  • Animals
  • Castration
  • Cell Division / drug effects*
  • Cell Transformation, Neoplastic / drug effects*
  • Cocarcinogenesis
  • DNA Damage
  • Estrogens / pharmacology
  • Male
  • Models, Biological
  • Nitrosamines / toxicity*
  • Prostatic Neoplasms / chemically induced
  • Prostatic Neoplasms / etiology*
  • Prostatic Neoplasms / pathology
  • Rats
  • Testosterone / pharmacology


  • Estrogens
  • Nitrosamines
  • Testosterone
  • nitrosobis(2-oxopropyl)amine