Pycnogenol prevents peritoneal adhesions

Arch Gynecol Obstet. 2015 Dec;292(6):1279-84. doi: 10.1007/s00404-015-3764-4. Epub 2015 Jun 2.

Abstract

Purpose: This study tested the ability of pycnogenol, an extract from the bark of the French maritime pine (Pinus pinaster), to prevent intra-abdominal adhesions.

Methods: Thirty female Wistar albino rats were separated randomly into three equal groups: Group (1) the control group, which underwent surgery, but was given no drug; Group (2) given 10 mg/kg of pycnogenol dissolved in normal saline intraperitoneally for 10 days after surgery; and Group (3) given 0.1 mL of normal saline for 10 days intraperitoneally after surgery. On post-operative day 10, all of the animals were killed and any adhesions were evaluated macroscopically and histopathologically.

Results: The macroscopic adhesion scores (mean ± SD) for Groups 1, 2, and 3 were 2.5 ± 0.53, 0.60 ± 0.70, and 2.0 ± 0.82, respectively. The macroscopic adhesion score was significantly lower in Group 2 than in Groups 1 and 3 (p < 0.001). All three components of the histopathological evaluation (inflammation, fibrosis, and neovascularization) were significantly lower in Group 2 than in Groups 1 or 3 (p < 0.001, p < 0.001, and p = 0.004, respectively).

Conclusions: Pycnogenol was found to be effective at preventing surgery-related adhesions in an animal model.

Keywords: Adhesions; Female; Intra-abdominal; Pycnogenol; Rat.

MeSH terms

  • Animals
  • Disease Models, Animal
  • Female
  • Fibrosis
  • Flavonoids / pharmacology*
  • Flavonoids / therapeutic use
  • Inflammation / pathology
  • Inflammation / prevention & control
  • Peritoneal Diseases / pathology
  • Peritoneal Diseases / prevention & control*
  • Phytotherapy*
  • Pinus / chemistry
  • Plant Extracts / therapeutic use*
  • Postoperative Complications / prevention & control
  • Rats
  • Rats, Wistar
  • Tissue Adhesions / pathology
  • Tissue Adhesions / prevention & control
  • Wound Healing / drug effects

Substances

  • Flavonoids
  • Plant Extracts
  • pycnogenols