Systematic Information to Health-Care Professionals about Vaccination Guidelines Improves Adherence in Patients With Inflammatory Bowel Disease in Anti-TNFα Therapy

Am J Gastroenterol. 2015 Nov;110(11):1526-32. doi: 10.1038/ajg.2015.162. Epub 2015 Jun 2.


Objectives: Implementation of guidelines for prevention of infectious diseases during anti-TNFα therapy in patients with inflammatory bowel disease (IBD) is important but difficult. We investigated whether systematic information to health-care professionals about these guidelines improves patients' adherence.

Methods: The study comprised three parts: (1) cross-sectional evaluation of baseline vaccination status in all IBD patients in anti-TNFα therapy (reference group; n=130); (2) prospective interventional study, where health-care professionals received systematic oral and written information about vaccination guidelines at baseline and at 2-month intervals for 6 months, followed by reassessment of vaccination status (intervention group; n=99); (3) cross-sectional evaluation of representative gastroenterologists' knowledge of guidelines (n=53). Outcomes were assessed by validated questionnaires.

Results: Patients' adherence to vaccination guidelines increased significantly after a period of systematic information to health-care professionals. Hence, complete adherence increased from 5 to 26%, partial adherence from 38 to 56%, and complete non-adherence decreased from 57 to 18% (P<0.0001). Adherence to all individual vaccinations except human papilloma virus increased significantly (P≤0.0021). Improvement was independent of disease type and anti-TNFα agent. At baseline, only 8% of physicians could identify all elements in the reference guideline. Additional barriers reported by physicians were forgetfulness (32%) and insufficient consultation time (26%). Patient-perceived barriers were costs of vaccinations (35%) and forgetfulness (25%).

Conclusions: Gastroenterologists' limited knowledge of vaccination guidelines during anti-TNFα therapy can be overcome by systematic education of health-care professionals. This inexpensive and easily accessible intervention immediately results in markedly improved patient adherence. Remaining obstacles for adherence comprise high vaccination costs and forgetfulness.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cross-Sectional Studies
  • Denmark
  • Female
  • Gastroenterology / statistics & numerical data*
  • Health Knowledge, Attitudes, Practice*
  • Humans
  • Inflammatory Bowel Diseases / drug therapy
  • Information Dissemination*
  • Male
  • Memory
  • Middle Aged
  • Patient Compliance / statistics & numerical data*
  • Practice Guidelines as Topic
  • Prospective Studies
  • Surveys and Questionnaires
  • Time Factors
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors
  • Vaccination / economics
  • Vaccination / standards*
  • Vaccination / statistics & numerical data*


  • Tumor Necrosis Factor-alpha