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Review
, 25 (7), 767-8

Targeted Genome Editing in Primate Embryos

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Review

Targeted Genome Editing in Primate Embryos

Xiangyu Guo et al. Cell Res.

Abstract

Mosaic mutations and off-target effects caused by CRISPR/Cas9 have led to concerns about the efficiency and specificity of this new technique in non-human primates and other large animals. Here we discuss recent findings from primate embryos, with a focus on the technical issues CRISPR/Cas9 faces before producing non-human primate models of human diseases.

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