Seroprevalence of measles, mumps, rubella and varicella antibodies in the United States population, 2009-2010

Emmaculate J Lebo; Deanna M Kruszon-Moran; Mona Marin; William J Bellini; Scott Schmid; Stephanie R Bialek; Gregory S Wallace; Huong Q McLean

doi:10.1093/ofid/ofv006

Seroprevalence of measles, mumps, rubella and varicella antibodies in the United States population, 2009-2010

Open Forum Infect Dis. 2015 Feb 20;2(1):ofv006. doi: 10.1093/ofid/ofv006. eCollection 2015 Jan.

Authors

Emmaculate J Lebo¹, Deanna M Kruszon-Moran², Mona Marin¹, William J Bellini¹, Scott Schmid¹, Stephanie R Bialek¹, Gregory S Wallace¹, Huong Q McLean³

Affiliations

¹ Division of Viral Diseases , Centers for Disease Control and Prevention , Atlanta, Georgia.
² Division of Health and Nutrition Examination Surveys , Center for Disease Control and Prevention , Hyattsville, Maryland.
³ Division of Viral Diseases , Centers for Disease Control and Prevention , Atlanta, Georgia ; Center for Clinical Epidemiology and Population Health , Marshfield Clinic Research Foundation , Wisconsin.

Abstract

Background. In the United States, measles, mumps, rubella, and varicella immunity is now primarily achieved through vaccination. Monitoring population immunity is necessary. Methods. We evaluated seroprevalence of antibodies to measles, mumps, rubella, and varicella using the National Health and Nutrition Examination Survey during 2009-2010. Results. Measles, mumps, rubella, and varicella seroprevalence was 92.0% (95% confidence interval [CI], 90.9%-93.0%), 87.6% (CI, 85.8%-89.2%), 95.3% (CI, 94.3%-96.2%), and 97.8% (CI, 97.1%-98.3%), respectively. United States (US)-born persons had lower mumps seroprevalence and higher varicella seroprevalence than non-US born persons. Conclusions. Seroprevalence was high (88%-98%) for all 4 viruses in the US population during 2009-2010.

Keywords: NHANES; antibodies; chickenpox; measles; mumps; rubella; seroepidemiologic studies..