Biochemical and histopathological effects of catechin on experimental peripheral nerve injuries

Turk Neurosurg. 2015;25(3):453-60. doi: 10.5137/1019-5149.JTN.12852-14.2.

Abstract

Aim: Catechin is a type of polyphenol, along with epicatechin, epigallocatechin, and epigallocatechin-gallate (EGCG). This study aims to investigate the effect of EGCG, a major metabolite of catechin, which is the principle bioactive compound in green tea, on rats with peripheral nerve injury.

Material and methods: A total of 74 rats were divided into six groups, namely the control, the trauma, the normal saline, a 25mg/kg EGCG, a 50mg/kg EGCG and a daily consumption group (10mg/kg EGCG was given intraperitoneally for 14 days before the trauma). Except the first group, the other groups underwent a 1-minute sciatic nerve compression by clip with 50gr/cm2 pressure. Nerve samples were obtained at 28 day after trauma for the biochemical and histopathological analysis.

Results: Our study showed that the Daily consumption, 25mg/kg EGCG and 50mg/kg EGCG groups demonstrated statistically significant decreased lipid peroxidation levels and particularly daily consumption, and the 25mg/kg EGCG group showed a favourable reduction of degeneration and edema histologically.

Conclusion: This study shows that Catechin and its derivatives have a protective effect on peripheral nerve injury.

MeSH terms

  • Animals
  • Catechin / administration & dosage
  • Catechin / analogs & derivatives*
  • Catechin / pharmacology
  • Disease Models, Animal
  • Male
  • Neuroprotective Agents / administration & dosage
  • Neuroprotective Agents / pharmacology*
  • Peripheral Nerve Injuries / drug therapy*
  • Rats
  • Rats, Wistar

Substances

  • Neuroprotective Agents
  • Catechin
  • epigallocatechin gallate