Current perspectives toward the identification of key players in gastric cancer microRNA dysregulation

Int J Cancer. 2016 Mar 15;138(6):1337-49. doi: 10.1002/ijc.29627. Epub 2015 Jun 16.


Acquired genetic and epigenetic alterations in normal cells give rise to transformed cells, which lead to tumor development. Elucidation of the precise mechanisms underlying primary and metastatic tumor formation is required. MicroRNAs (miRNAs) are small noncoding RNAs that play a major role in post-transcriptional gene regulation during various biological processes. Accumulating evidence suggests that dysregulation of miRNAs is intimately involved in the carcinogenesis, progression and metastasis of many cancers, including gastric cancers (GCs), while the alteration of certain miRNAs provides biomarkers to detect early GCs. This review summarizes the most recent findings into the mechanisms of miRNA-mediated regulation of GCs, which will support the development of diagnostic biomarkers and novel therapeutic strategies.

Keywords: H. pylori; cancer biomarker; gastric cancer; microRNA; therapeutic target.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biomarkers, Tumor
  • Cell Movement / genetics
  • Cell Transformation, Neoplastic / genetics
  • Disease Progression
  • Drug Resistance, Neoplasm / drug effects
  • Gene Expression Regulation, Neoplastic*
  • Host-Pathogen Interactions / genetics
  • Humans
  • MicroRNAs / blood
  • MicroRNAs / genetics*
  • Neoplasm Invasiveness
  • Neoplasm Metastasis
  • Neovascularization, Pathologic / genetics
  • Prognosis
  • Stomach Neoplasms / diagnosis
  • Stomach Neoplasms / drug therapy
  • Stomach Neoplasms / genetics*
  • Stomach Neoplasms / microbiology
  • Stomach Neoplasms / mortality


  • Biomarkers, Tumor
  • MicroRNAs