Green synthesis, characterization of gold and silver nanoparticles and their potential application for cancer therapeutics

Mater Sci Eng C Mater Biol Appl. 2015 Aug;53:298-309. doi: 10.1016/j.msec.2015.04.048. Epub 2015 May 1.

Abstract

In the present article, we demonstrate the delivery of anti-cancer drug to the cancer cells using biosynthesized gold and silver nanoparticles (b-AuNP & b-AgNP). The nanoparticles synthesized by using Butea monosperma (BM) leaf extract are thoroughly characterized by various analytical techniques. Both b-AuNP and b-AgNP are stable in biological buffers and biocompatible towards normal endothelial cells (HUVEC, ECV-304) as well as cancer cell lines (B16F10, MCF-7, HNGC2 & A549). Administration of nanoparticle based drug delivery systems (DDSs) using doxorubicin (DOX) [b-Au-500-DOX and b-Ag-750-DOX] shows significant inhibition of cancer cell proliferation (B16F10, MCF-7) compared to pristine drug. Therefore, we strongly believe that biosynthesized nanoparticles will be useful for the development of cancer therapy using nanomedicine approach in near future.

Keywords: Biocompatible; Butea monosperma; Cancer therapy; Drug delivery systems; Gold and silver nanoparticles; Green synthesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacokinetics
  • Antineoplastic Agents / pharmacology
  • Butea
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Doxorubicin / chemistry
  • Doxorubicin / pharmacokinetics
  • Doxorubicin / pharmacology
  • Drug Delivery Systems*
  • Gold / chemistry*
  • Gold / pharmacokinetics
  • Green Chemistry Technology
  • Humans
  • Metal Nanoparticles / chemistry*
  • Mice
  • Plant Extracts / metabolism
  • Silver / chemistry*
  • Silver / pharmacokinetics

Substances

  • Antineoplastic Agents
  • Plant Extracts
  • Silver
  • Gold
  • Doxorubicin